Clinical Trials

Pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

Appraisal of: Banno, M et al (2019) Studies registered in non-ClinicalTrials.gov accounted for an increasing proportion of protocol registrations in medical research. J Clin Epidemiol 2019;116:106.

Appraisal of: Wieseler B, Wolfram N, McGauran N et al. Completeness of reporting of patient-relevant clinical trial outcomes: comparison of unpublished clinical study reports with publicly available data. PLoS Med 2013;10(10):e1001526.

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